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Master Your HPCSA Medical Boards with Confidence QuestMed delivers comprehensive exam preparation with 7,000+ questions crafted specifically for South African medical graduates. Our mix of AI-generated and human-created questions covers every topic from the latest STGs and EML guidelines to verified post-exam recalls.

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Question of the Day

A 45-year-old HIV-positive man (CD4 count 65 cells/µL, viral load 550,000 copies/mL) not on ART presents with confusion, fever, and seizures. CSF analysis shows: protein 1.5 g/L, glucose 1.2 mmol/L, 8 lymphocytes/mm³, positive cryptococcal antigen, and positive India ink. After starting amphotericin B and flucytosine, when should ART be initiated according to South African guidelines?

Explanation: According to South African guidelines, in patients with cryptococcal meningitis, ART should be deferred until 4-6 weeks after starting antifungal therapy to reduce the risk of immune reconstitution inflammatory syndrome (IRIS).

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